Results
| PMID | 8752605 |
| Gene Name | CCL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 57 |
| Population details | 57 (36 women presenting for infertility, pelvic pain, or tubal ligation in which endometriosis was diagnosed at laparoscopy, 21 normal fertile controls presenting for tubal ligation) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | MCP-1 |
| Other associated phenotypes |
Endometriosis associated with infertility, pelvic pain |
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Fertil Steril. 1996 Jul;66(1):17-23. Akoum, A| Lemay, A| McColl, S| Turcot-Lemay, L| Maheux, R Departement d'Obstetrique-Gynecologie, Faculte de Medecine, Universite Laval, Sainte-Foy, Quebec, Canada. OBJECTIVE: To estimate the concentration and the biologic activity of monocyte chemotactic protein-1 (MCP-1) in the peritoneal fluid (PF) of women with and without endometriosis. DESIGN: A case control study was conducted. SETTING: Gynecology clinic and Laboratories of endocrinology of reproduction and immunology. PATIENTS: Women presenting for infertility, pelvic pain, or tubal ligation in which endometriosis was diagnosed at laparoscopy (n = 36) and normal fertile controls presenting for tubal ligation (n = 21). INTERVENTIONS: Collection of PF via laparoscopy. MAIN OUTCOME MEASURES: Determination of PF concentrations of MCP-1 by an ELISA and evaluation of its monocyte chemotactic activity using a human hystiocytic cell line (U937). RESULTS. The concentration of MCP-1 (median, range of values) was increased in the PF of endometriosis patients (283, 0 to 1,930 pg/mL; conversion factor to SI unit, 0.155) compared with the control group (140, 0 to 435 pg/mL). The most significant elevation of MCP-1 levels was found in the stage II of the disease (371, 200 to 1,930 pg/mL). An increased chemotactic activity for monocytes (mean number of migrating cells/mm2 +/- SD) also was found in stages I (1,460 +/- 312) and II (1,541 +/- 336) of the disease when compared with fertile controls (393 +/- 56). Forty percent to 53% of this activity was inhibited in the presence of an antibody specific to MCP-1. CONCLUSIONS: These observations are consistent with previous data indicating increased leukocyte chemotaxis in the PF of patients with endometriosis and suggest that MCP-1 may play a relevant role in the peritoneal inflammatory reaction associated with the disease. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Case-Control Studies| Chemokine CCL2/*metabolism| Chemotaxis, Leukocyte| Endometriosis/*metabolism| Female| Humans| Monocytes/physiology| Osmolar Concentration|DA 1996/07/01 00:01 |
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